^a麻根碱C ^bhedradine C
有效成分: ^a麻根碱C ^bhedradine C
异名: 无
化学名: 4H-1, 16-Etheno-5,15-(propaniminoethano) furo [3,4-1][1,5,10] triazacycleohexadecine-4,21-dione, 3, 3a, 6, 7, 8, 9 ,10, 11, 12, 13, 14, 15-dodecahydro-3-(3,4-dimethoxyphenyl)-, [3R-(3R↑*,3aR↑*,15S↑*)]
结构式: str-0475
分子式/分子量: ^aC↓30H↓40N↓4O↓5; ^b536. 65
临床: 未
成分分类: 生物碱类
物理性状: 未分得游离碱结晶。二氢溴酸盐(C↓30H↓40N↓4O↓5？2HBr？H↓2O)熔点224？225°,[α]↓D-100.7°(水)↑[1]。↑13CNMR (D↓2O)σ: (d, C-2), 52.0 (d, C-3), 125.8 (s, C-4), 133.4 (d, C-5), 126.1 (s, C-6), 121.0 (d, C-7), 111.3 (d, C-8), 159.1 (s, C-9), 130.7 (s, C-10), 110.4 (d, C-11), 148.4 (s, C-12), 148.0 (s, C-13), 109.8 (d, C-14), 119.7 (d, C-15), 170.7 (s, C-16), 58.7 (d, C-17), 174.5 (s, C-19), 21.4 (t, C-18), 22.8 (t, C-2'), 25.2 (t, C-13'), 25.4 (t, C-13'), 37.7 (t), 37.9 (t), 41.9 (t), 42.6 (t), 44.2 (t), 46.0 (t), 46.0 (t), 55.5 (q, CH↓3O), 55.5 (q)↑[1]。
来源: ^a麻黄科^b麻黄属 Ephedra ^c植物的根。
作用: 大鼠静脉注射本品二氢溴酸盐2.0mg/kg时,能引起明显的血压降低↑[1]。
参考文献: 1. Heterocycles 14(3):295, 1980; C. A. 92:143246v, 1980; C. A. 93:53858n, 1980
用途分类: 降血压