^a麻黄根碱B ^bEphedradine B
有效成分: ^a麻黄根碱B ^bEphedradine B
异名: 无
化学名: 4H-1, 16-Etheno-5, 15-(propaniminoethano) furo [3,4-1] [1,5,10] triazacycleohexadecine-4, 21-dione, 3, 3a, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-3(4-hydroxy-3-methoxyphenyl)-, [3R-(3R↑*, 3aR*↑, 15S↑*)]
结构式: str-0474
分子式/分子量: ^aC↓29H↓38N↓4O↓5; ^b522.63
临床: 未
成分分类: 生物碱类
物理性状: 未分得游离碱结晶。二溴酸盐(C↓29H↓38N↓4O↓5？2HBr？H↓2O) 熔点219？221°, [α]↓D-101.5°(水)。↑13CNMR (D↓2O)σ: 88.7 (s, C-2), 52.5 (s, C-3), 125.3 (s, C-4), 134.3 (d, C-5), 126.9 (s, C-6), 121.5 (d, C-7), 111.1 (d, C-8), 159.9 (s, C-9), 130.8 (s, C-10), 111.1 (d, C-11), 147.9 (s, C-12), 145.9 (s, C-13), 115.7 (d, C-14), 120.5 (d, C-15), 171.1 (s, C-16), 59.2 (d, C-17), 175.2 (s, C-19), 21.8 (t, C-18), 23.1 (t, C-2'), 25.7 (t, C-13'), 25.7 (t, 38.0(t), 42.3 (t), 42.7 (t), 44.8 (t), 46.5 (t), 46.5 (t), 56.4 (q, CH↓3O)↑[1]。
来源: ^a麻黄科^b麻黄属( Ephedra) ^c植物的根↑[1]。
作用: 大鼠静脉注射本品的二氢溴酸盐2.0mg/kg时,能引起明显的血压降低↑[1]。
参考文献: 1. Hetercycles 12(6):783, 1979; C. A. 92:143246v, 1980; C. A. 94:140007y, 1981, 93:53858n, 1980
用途分类: 降血压