^a环毛穗胡椒碱 A ^bCyclostachine A
有效成分: ^a环毛穗胡椒碱 A ^bCyclostachine A
异名: 无
化学名: Pyrrolidine, 1-[[2-(1,3-benzodioxo-5-yl)-1,2,4a,5,6,7,8,8a,-octahydro-1-naphthalenyl]carbonyl]-,(1α,2β,4aα,8aα)-(±)-
结构式: str-0357
分子式/分子量: ^aC↓22H↓27NO↓3; ^b353.44
临床: 未
成分分类: 生物碱类
物理性状: 无色立方结晶, 熔点136？138°(乙醚-已烷)。UVλ↑EtOH↓max nm(logε):235(3.65),287(3.62);IRν↑MBr↓max cm↑-1:1640,1500,1480,14330,1380,1245,1190,1115,1100,1035,970,925,900,880,870,832,812,800,758,750,730,720;MSm/e(％):353(M↑+,100),270(45),255(44),254(90),240(18),218(45),212(8),211(15),204(8),181(6),169(6),153(10),152(10),148(12),141(14),1359780,128(20),115(25),103(12),98(95),91(24),77(22),70(24),56(35),55(92);NMR(CDCI↓3)δ:6.7(M,H↑2,5,6),3.68(d,q,J↓7,18=10.0,H↓7),5.55(br.d,J↓8,9=10,H↓8),5.9(d,d,d,J↓9,8=10,J↓9,10=5,J↓9,7=2.5,H↓9),3.15(d,t,J↓10,11a=10,J↓10,11e=6,J↓10,9=6,H↓10);↑13CNMR(CDCI↓3)δ:173.6(C-17),147.7和146.3(C-3,4),138.7(C-1),133.4,128.5和121.0(C-6,8,9),108.4和108.1(C-2,5),101.0(C-22),47.2和46.8(C-7,16),46.4和45.4(C-18,21),36.6和35.6(C-10,15),30.6,28.8,26.8,26.0,24.3和22.1(C-11,12,13,14,19,20)↑[2]。
来源: ^a胡椒科植物^b毛穗胡椒 Piper trichostachyon C.DC.^c茎[1,2]。
作用: 具有镇静、抗惊厥、抗菌及抗菌作用↑[3]。
参考文献: 1.C. A. 83:17938c, 1975; 84:105865y, 1976;2. Helv. Chim. Acta 58:2295, 1975;3. H. Wanger et al: Natural Products and Plant Drugs with Pharmacological; Biological or Therapeutical Activity 215, 1977
用途分类: 抗菌, 抗真菌, 镇静, 抗惊厥