^a去甲氧利血平 ^bDeserpidine
有效成分: ^a去甲氧利血平 ^bDeserpidine
异名: 坎尼生, Canescifne,11-Dismethoxyreserpine, Recanescine, Raunorimin, Harmonyl, Reserpidine
化学名: Yohimban-16-carbocylic acid, 17-methoxy 18-[(3, 4, 5-trimethoxybenzoyl) oxy]-, methyl este,r (3β, 16β, 1α7, 18β, 20α)-
结构式: str-0409
分子式/分子量: ^aC↓32H↓38N↓2O↓8; ^b578.64
临床: 用于降血压。
成分分类: 生物碱
物理性状: 有三种结晶形态(甲醇): α-型, 熔点228？232°;β-型, 熔点230？232°; γ-型, 双熔点138°及226？232°(175°固化)。[α]↑20↓D-163°(c=0.5, 吡啶)。↑13CNMR (CS2): 61.8 (C-2), 133.0 (C-3), 140.1 (C-5), 176.8 (C-6), 85.5 (C-7), 65.3 (C-8), 74.0 (C-9), 72.1 (C-10), 75.4 (C-11), 57.2 (C-13), 159.4 (C-14), 161.0 (C-15), 141.4 (C-16), 115.5 (C-17), 115.5 (C-18), 169.4 (C-19), 163.8 (C-20), 144.0(C-21), 20.3 (C-22), 141.6 (C-23), 141.6 (C-24), 27.3 (C-25), 67.8 (C-26), 86.2 (C-27), 39.8 (C-28), 50.7 (C-29), 137.4 (C-30), 133.1 (C-31)↑[1]; IRν↓ max cm↑-1: 3450, 2940, 1720, 1590, 1470, 1410, 1330, 1250, 1220,1120,1010,980,950,900,740; UVλ↑acoh↓max NM(ε):271(19055);MSm/e:578(100),547(75),577(66),365(32),367(25),195(25),366(20),351(20)↑[]。
来源: ^a夹竹桃科植物^b灰白毛萝芙木 Rauwolfia canescens L. ^c根[3,4], ^b蛇根木 Rauwolfia serpentina (L.) Benth. et Hook. f. (Ophioxylon serpentium L.) ^c根[3]^b催吐萝芙木 Rauwolfia vomitoria Afzel. ex Spreng. ^c根[3]
作用: 作用用途与利血平相似, 但其降压作用强度仅为利血平的一半, 中枢镇静作用也较弱。不良反应则较利血平少见↑[5]。适用于轻度原发性高血压, 大教师民苯噻嗪类合并应用。也可用于轻度焦虑↑[5]。有呕吐、腹泻、头痛、鼻充血等不良反应。胃及十二指肠溃疡者禁用↑[5]。
参考文献: 1. J. Org. CHem. 38(11):1983, 1973; 2. Atlas of Spectral Data and Physical Constants for Organic Compounds 2ed. Vol. Ⅲ, 174, 1975; 3. J. Amer. Chem. Soc. 77:820, 1955; J. Amer. Chem. Soc. 77:4084, 1955; J. Amer. Chem. Soc. 77:4087, 1955; J. Amer. Chem. Soc. 77:4335, 1955; 4. C. A. 88:141759h, 1978; 5. 药品集编写组: 药品集第一分册(心血管系统药物) 175, 1976
用途分类: 降血压, 镇静, 毒性